DNA polymerase clamp loaders and DNA recognition
نویسندگان
چکیده
منابع مشابه
The PCNA-RFC families of DNA clamps and clamp loaders.
The proliferating cell nuclear antigen PCNA functions at multiple levels in directing DNA metabolic pathways. Unbound to DNA, PCNA promotes localization of replication factors with a consensus PCNA-binding domain to replication factories. When bound to DNA, PCNA organizes various proteins involved in DNA replication, DNA repair, DNA modification, and chromatin modeling. Its modification by ubiq...
متن کاملThe sliding clamp of DNA polymerase III holoenzyme encircles DNA.
DNA polymerases that duplicate chromosomes are remarkably processive multiprotein machines. These replicative polymerases remain in continuous association with the DNA over tens to hundreds of kilobases. What is the chemical basis of their strong grip to the template? The mystery behind the high processivity of the replicative polymerase of the Escherichia coli chromosome, DNA polymerase III ho...
متن کاملHow a DNA polymerase clamp loader opens a sliding clamp.
Processive chromosomal replication relies on sliding DNA clamps, which are loaded onto DNA by pentameric clamp loader complexes belonging to the AAA+ family of adenosine triphosphatases (ATPases). We present structures for the ATP-bound state of the clamp loader complex from bacteriophage T4, bound to an open clamp and primer-template DNA. The clamp loader traps a spiral conformation of the ope...
متن کاملClamp loaders and sliding clamps.
A coherent view of the structure and function of DNA polymerase processivity factors (sliding clamps and clamp loaders) is emerging from recent structural studies. Crystal structures of sliding clamps from the T4 and RB69 bacteriophages, and from an archaebacterium expand the gallery of ring-shaped processivity factors and clarify how the clamp interacts with the DNA polymerase. Crystallographi...
متن کاملStructure and Mechanism of the DNA Polymerase Processivity Clamp Loader
The replication of a genome is a fundamental biological process that every organism must perform in order to transmit its genetic makeup to its progeny. We have been studying the molecular machines that are used to rapidly and accurately replicate the DNA genome of bacteria. In addition to the polymerase (the actual copying machine), organisms have a set of assemblies that enable the polymerase...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2004
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2004.11.038